原创力文档computer-assisted anti-aids drug development cyclophilin b against the hiv-1 subtype a v3 loop计算机辅助抗艾滋病药物开发还有b对hiv - 1亚型v3循环.pdfVIP
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computer-assisted anti-aids drug development cyclophilin b against the hiv-1 subtype a v3 loop计算机辅助抗艾滋病药物开发还有b对hiv - 1亚型v3循环
Vol.2, No.7, 661-671 (2010) Health
doi:10.4236/health.2010.27100
Computer-assisted anti-AIDS drug development:
cyclophilin B against the HIV-1 subtype A V3 loop
1 2
Alexander M. Andrianov *, Ivan V. Anishchenko
1Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus;
*
Corresponding Author: andrianov@iboch.bas-net.by
2United Institute of Informatics Problems, National Academy of Sciences of Belarus, Minsk, Belarus
Received 16 December 2009; revised 24 March 2010; accepted 26 March 2010.
ABSTRACT gp120 envelope protein was constructed and
analyzed. Conclusions: Starting from the joint
Aim: The objects of this study originated from analysis of the results derived with those of the
the experimental observations, whereby the HIV literature, the generated peptide was suggested
-1 gp120 V3 loop is a high-affinity ligand for to offer a promising basic structure for making a
immunophilins, and consisted in generating the reality of the protein engineering projects aimed
structural complex of cyclophilin (Cyc) B be- at developing the anti-AIDS drugs able to stop
longing to immunophilins family with the virus the HIV’s spread.
subtype A V3 loop (SA-V3 loop) as well as in
specifying the Cyc B segment forming the Keywords: HIV-1; V3 Loop; Cyclophilin B;
binding site for V3 synthetic copy of which, on Computer Modeling; Molecular Docking;
the assumption of keeping the 3D peptide struc-
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