原创力文档context dependent auditory thresholds determined by brainstem audiometry and prepulse inhibition in mongolian gerbils上下文依赖听觉阈值由脑干听力测定,在蒙古沙鼠前脉冲抑制.pdfVIP
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context dependent auditory thresholds determined by brainstem audiometry and prepulse inhibition in mongolian gerbils上下文依赖听觉阈值由脑干听力测定,在蒙古沙鼠前脉冲抑制
Open Journal of Acoustics, 2012, 2, 34-49
/10.4236/oja.2012.21004 Published Online March 2012 (http://www.SciRP.org/journal/oja)
Context Dependent Auditory Thresholds Determined by
Brainstem Audiometry and Prepulse Inhibition in
Mongolian Gerbils
* *
Markus Walter , Konstantin Tziridis , Sönke Ahlf, Holger Schulze
Experimental Otolaryngology, University of Erlangen-Nuremberg, Erlangen, Germany
*
Email: holger.schulze@uk-erlangen.de
Received October 28, 2011; revised November 30, 2011; accepted December 14, 2011
ABSTRACT
Information on hearing thresholds is not always reliable as differences in these thresholds have been described even for
the same species. This may partially be due to different methods used by different labs. A frequently used approach to
obtain an estimate of hearing threshold is the electrophysiological recording of auditory brainstem responses (ABR).
They are usually recorded under deep anesthesia and represent the auditory evoked far-field potentials at various levels
in the central auditory pathway. Alternatively, several behavioral approaches are employed. These commonly use oper-
ant or classical conditioning to determine hearing thresholds. A potential disadvantage of these methods is that any
sound conditioning may in principle alter auditory perception and therefore auditory thresholds. To exclude this type of
methodological bias a prepulse inhibition (PPI) paradigm can be used where an audiogram can be determined without
any kind of pre-training. Here we compare the threshold estimates obtained by two different ABR and PPI measure-
ments where stimuli are presented i
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