correlation of gleason scores with diffusion-weighted imaging findings of prostate cancer格里森评分的相关性与diffusion-weighted前列腺癌的影像学表现.pdfVIP

Hindawi Publishing Corporation Advances in Urology Volume 2012, Article ID 374805, 5 pages doi:10.1155/2012/374805 Research Article Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer Rajakumar Nagarajan,1 Daniel Margolis,1 Steven Raman,1 Ke Sheng,2 Christopher King,2 Robert Reiter,3 and M. Albert Thomas1 1 Department of Radiological Sciences, David Geff en School of Medicine, University of California, Los Angeles, CA 90095-1721, USA 2 Department of Radiation Oncology, David Geff en School of Medicine, University of California, Los Angeles, CA 90095-1721, USA 3 Department of Urology, David Geff en School of Medicine, University of California, Los Angeles, CA 90095-1721, USA Correspondence should be addressed to M. Albert Thomas, athomas@ Received 15 August 2011; Revised 5 October 2011; Accepted 5 October 2011 Academic Editor: Jack Schalken Copyright © 2012 Rajakumar Nagarajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of prostate cancer (PCa) patients with three classes of pathological Gleason scores (GS). Patients whose GS met these criteria (GS 3 + 3, GS 3 + 4, and GS 4 + 3) were included in this study. The DWI was performed using b values of 0, 50, and 400 s/mm2 in 44 patients using an endorectal coil on a 1.5T MRI scanner. The apparent diffusion coefficient (ADC) values were calculated from the DWI data of patients with three different Gleason scores. In patients with a high-grade Gleason score (4 + 3), the ADC values were l