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current state of nanoemulsions in drug delivery当前状态的这种药
Journal of Biomaterials and Nanobiotechnology, 2011, 2, 626-639
doi:10.4236/jbnb.2011.225075 Published Online December 2011 (/journal/jbnb)
Current State of Nanoemulsions in Drug Delivery
*
Charles Lovelyn, Anthony A. Attama
Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria.
* *
E-mail: anthony.attama@.ng, aaattama@
Received September 20th, 2011; revised October 27th, 2011; accepted November 14th, 2011.
ABSTRACT
Nanoemulsions have attracted great attention in research, dosage form design and pharmacotherapy. This is as a result
of a number of attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, thermodynamic stabil-
ity and increased surface area. Nanoemulsions also known as submicron emulsions serve as vehicles for the delivery of
active pharmaceutical ingredients as well as other bioactives. They are designed to address some of the problems asso-
ciated with conventional drug delivery systems such as low bioavailability and noncompliance. The importance of de-
sign and development of emulsion nanocarrier systems aimed at controlling and/or improving required bioavailability
levels of therapeutic agents cannot be overemphasized. Reducing droplet sizes to the nanoscale leads to some very in-
teresting physical properties, such as optical transparency and unusual elastic behaviour. This review sheds light on
the current state of nanoemulsions in the delivery of drugs and other bioactives. The morphology, formulation, charac-
teristics and characterization of nanoemulsions were also addressed.
Keywords : Nanoemulsion, Preparation, Characterization, Application in Drug Delivery, Patents
1. Introduction drug therapy period as these emulsions guarantee the
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