cytokines in pericardial effusion of patients with inflammatory pericardial disease细胞因子在炎症性心包疾病患者的心包积液.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 382082, 7 pages doi:10.1155/2012/382082 Clinical Study Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease Konstantinos Karatolios,1 Rainer Moosdorf,2 Bernhard Maisch,1 and Sabine Pankuweit1 1 Department of Cardiology, University Hospital Gießen Marburg, Baldinger Straße, 35043 Marburg, Germany 2 Department of Heart Surgery, University Hospital Gießen Marburg, Baldinger Straße, 35043 Marburg, Germany Correspondence should be addressed to Konstantinos Karatolios, karatoli@med.uni-marburg.de Received 4 November 2011; Revised 1 February 2012; Accepted 2 February 2012 Academic Editor: Franc¸ois Mach Copyright © 2012 Konstantinos Karatolios et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain. Methods. We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (n = 22) and viral (n = 11) origin, and for control in pericardial fluid (PF) and serum (n = 26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery. Results. VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (P = 0, 006 for autoreactive and P 0, 001 for viral PE) and serum (P 0, 001 for autoreactive and P 0, 001 for viral PE). Pericardial bFGF levels were higher comp