原创力文档deficiency in poly(adp-ribose) polymerase-1 (parp-1) accelerates aging and spontaneous carcinogenesis in mice保利(adp-ribose)polymerase-1不足(parp-1)加速衰老和自发的老鼠体内的致癌作用.pdfVIP
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deficiency in poly(adp-ribose) polymerase-1 (parp-1) accelerates aging and spontaneous carcinogenesis in mice保利(adp-ribose)polymerase-1不足(parp-1)加速衰老和自发的老鼠体内的致癌作用
Hindawi Publishing Corporation
Current Gerontology and Geriatrics Research
Volume 2008, Article ID 754190, 11 pages
doi:10.1155/2008/754190
Research Article
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1)
Accelerates Aging and Spontaneous Carcinogenesis in Mice
Tatiana S. Piskunova,1 Maria N. Yurova,1 Anton I. Ovsyannikov,1 Anna V. Semenchenko,1
Mark A. Zabezhinski,1 Irina G. Popovich,1 Zhao-Qi Wang,2, 3 and Vladimir N. Anisimov1
1 Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2,
St. Petersburg 197758, Russia
2 Leibniz Institute for Age Research, Fritz Lipman e.V., 07745 Jena, Germany
3 Faculty of Biology and Pharmacy, Friedrich-Schiller-University of Jena, 07737 Jena, Germany
Correspondence should be addressed to Vladimir N. Anisimov, aging@mail.ru
Received 20 September 2007; Revised 4 December 2007; Accepted 13 February 2008
¨
Recommended by Alexander Burkle
Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair,
genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis
of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1−/ − mice exhibit a
reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight
gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological
aging in PARP-1−/ − mice. The incidence of spontaneous tumors in both PARP-1−/ − and PARP-1+/ + groups is similar; however,
malignant tumors including
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