development and validation of dissolution test for fluconazole capsules by hplc and derivative uv spectrophotometry开发和验证解散测试氟康唑胶囊通过高效液相色谱法和紫外导数分光光度法.pdfVIP

Hindawi Publishing Corporation Chromatography Research International Volume 2012, Article ID 610427, 8 pages doi:10.1155/2012/610427 Research Article Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry ˆ 1 2 Josilene Chaves Ruela Correa, Cristina Duarte Vianna-Soares, ´ 1 and Herida Regina Nunes Salgado 1 School of Pharmaceutical Sciences, Universidade Estadual Paulista, Rodovia Araraquara-Jau km 1, 14801-902 Araraquara, SP, Brazil ´ 2 Department of Pharmaceutical Products, Federal University of Minas Gerais, Avenida Antonio Carlos 6627, ˆ 31270-901 Belo Horizonte, MG, Brazil ˆ Correspondence should be addressed to Josilene Chaves Ruela Correa, josilenechavescorrea@ Received 7 December 2011; Revised 26 January 2012; Accepted 27 January 2012 Academic Editor: Bengi Uslu ˆ Copyright © 2012 Josilene Chaves Ruela Correa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The purpose of this study is to develop and validate a dissolution test for fluconazole, an antifungal used for the treatment of superficial, cutaneous, and