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Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 456456, 14 pages doi:10.1155/2012/456456 Review Article Does Inflammation Determine Whether Obesity Is Metabolically Healthy or Unhealthy? The Aging Perspective Iftikhar Alam,1, 2 Tze Pin Ng,3 and Anis Larbi4 1 Tubingen Aging and Tumor Immunology (TATI) Group, University of Tubingen (ZMF), Waldhornlestrasse 22, 72072 Tubingen, Germany 2 Faculty of Agriculture, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa (KPK), Mardan 25000, Pakistan 3 Department of Psychological Medicine, National University Health System, Gerontological Research Programme, National University of Singapore, Singapore 119228 4 Singapore Immunology Network (SIgN), Biopolis, Agency for Science, Technology and Research (A∗STAR), Singapore 138648 Correspondence should be addressed to Anis Larbi, anis larbi@.sg Received 1 June 2012; Revised 30 August 2012; Accepted 5 September 2012 Academic Editor: Peter Plomgaard Copyright © 2012 Iftikhar Alam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Obesity is a major health issue in developed as well as developing countries. While obesity is associated with relatively good health status in some individuals, it may become a health issue for others. Obesity in the context of inflammation has been studied extensively. However, whether obesity in its various forms has the same adverse effects is a matter of debate and requires further research. During its natural history, metabolically healthy obesity (MHO) converts into metabolically unhealthy obesity (MUHO). What causes this transition to occur and