原创力文档does magnesium sulfate increase the incidence of postpartum hemorrhage a systematic review硫酸镁是增加产后出血的发生率系统回顾.pdfVIP
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does magnesium sulfate increase the incidence of postpartum hemorrhage a systematic review硫酸镁是增加产后出血的发生率系统回顾
Open Journal of Obstetrics and Gynecology, 2011, 1, 168-173 OJOG
doi:10.4236/ojog.2011.14032 Published Online December 20 11 (http://www.SciRP.org/journal/ojog/).
Does magnesium sulfate increase the incidence of postpartum
hemorrhage? A systematic review
Laura M. Héman, Paul J. Q. Van Der Linden
Department of Gynaecology and Obstetrics, Deventer Ziekenhuis, Deventer, The Netherlands.
Email: p.j.q.vanderlinden@dz.nl
Received 4 October 2011; revised 22 November 2011; accepted 3 December 20 11.
ABSTRACT because of three following effects.
Firstly, magnesium sulfate is widely used in obstetri-
The incidence of Postpartum Hemorrhage (PPH) is
cal care for the prevention of eclampsia during preg-
increasing in the western world. We hypothesize that
nancy, although the exact pharmacological mechanism
magnesium sulfate (MgSO4) could be a contributing
of MgSO4 in preventing eclampsia is not known [3]. Ce-
factor. MgSO4 might increase the incidence of PPH
rebral vasoconstriction has been reported in women with
by induction of vasodilation, tocolytic effects, and
eclampsia [4]. Magnesium sulfate vasodilates intracra-
effects on the blood like red cell deformity, platelet
nial vessels dista
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