drug-carrying magnetic nanocomposite particles for potential drug delivery systemsdrug-carrying磁性纳米粒子为潜在的药物输送系统.pdfVIP

Hindawi Publishing Corporation Journal of Nanotechnology Volume 2009, Article ID 238536, 6 pages doi:10.1155/2009/238536 Research Article Drug-Carrying Magnetic Nanocomposite Particles for Potential Drug Delivery Systems R. Asmatulu,1 A. Fakhari,2 H. L. Wamocha,1 H. Y. Chu,3 Y. Y. Chen,3 M. M. Eltabey,1, 4 H. H. Hamdeh,5 and J. C. Ho3, 5 1 Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA 2 Department of Bioengineering, University of KS, Lawrence, KS, USA 3 Institute of Physics, Academia Sinica, Taipei, Taiwan 4 Department of Basic Engineering Science, Menoufiya University, Shebin, Egypt 5 Department of Physics, Wichita State University, Wichita, KS, USA Correspondence should be addressed to R. Asmatulu, ramazan.asmatulu@ Received 10 May 2009; Accepted 5 August 2009 Recommended by Sakhrat Khizroev Drug-carrying magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co- glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼13 nm on average) of magnetite were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hours agitation for the synthesis of nanocomposite spheres. Specifically, PLGA and drug were first dissolved in acetonitrile (oily phase I) and combined with magnetic nanoparticles, then added dropwise into viscous paraffin oil combined with Span 80 (oily phase II). With different contents (0%, 10%, 20%, and 25%) of magnetite, the nanocomposite spheres were evaluated in terms of particle size, morphology,