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dti and structural mri classification in alzheimer’s diseasedti mri和结构分类在阿尔茨海默氏症
Advances in Molecular Imaging , 2012, 2, 12-20
/10.4236/ami.2012.22003 Published Online April 2012 (http://www.SciRP.org/journal/ami)
DTI and Structural MRI Classification in
Alzheimer’s Disease
1,2,3 2,3,4 5 2
Lilia Mesrob , Marie Sarazin , Valerie Hahn-Barma , Leonardo Cruz de Souza ,
Bruno Dubois2,4,5 1 2,3,6
, Patrick Gallinari , Serge Kinkingnéhun
1LIP6, Université Pierre et Marie Curie, Paris, France
2Université Pierre et Marie Curie, Paris, France
3Institute of Neurofunctional Imagery, Gif-sur-Yvette, France
4Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France
5Research and Resource Memory Centre, Pitié-Salpêtrière Hospital, Paris, France
6e(ye)BRAIN, Ivry-sur-Seine, France
Email: lmesrob@yahoo.fr
Received February 21, 2012; revised March 19, 2012; accepted April 18, 2012
ABSTRACT
In this paper, we propose a fully automated method to individually classify patients with Alzheimer’s disease (AD) and
elderly control subjects based on diffusion tensor (DTI) and anatomical magnetic resonance imaging (MRI). We pro-
pose a new multimodal measure that combines anatomical and diffusivity measures at the voxel level. Our approach
relies on whole-brain parcellation into 73 anatomical regions and the extraction of multimodal characteristics in these
r
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