原创力文档effect of nicotine on dopamine and glutathione levels in presence of oligoelements in brain regions of young rats——effect of nicotine on brain regions of rat尼古丁对多巴胺和谷胱甘肽水平的影响在年轻的老鼠的大脑区域存在少量元素u2014u2014尼古丁对老鼠的大脑区域的影响.pdfVIP
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effect of nicotine on dopamine and glutathione levels in presence of oligoelements in brain regions of young rats——effect of nicotine on brain regions of rat尼古丁对多巴胺和谷胱甘肽水平的影响在年轻的老鼠的大脑区域存在少量元素u2014u2014尼古丁对老鼠的大脑区域的影响
Neuroscience Medicine, 2012, 3, 281-286 281
/10.4236/nm.2012.33032 Published Online September 2012 (http://www.SciRP.org/journal/nm)
Effect of Nicotine on Dopamine and Glutathione Levels in
*
Presence of Oligoelements in Brain Regions of Young Rats
——Effect of Nicotine on Brain Regions of Rat
1 1 2
David Calderón Guzmán , Ernestina Hernández García , Francisca Trujillo Jiménez ,
Gerardo Barragán Mejía1 2,3# 3
, Hugo Juárez Olguín , José A. Saldivar González ,
Daniel Santamaria del Angel1, Norma Osnaya Brizuela4
1Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP), México City, México; 2Laboratorio de Farmacología, INP,
México City, México; 3Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, México
City, México; 4Laboratorio de Patología Experimental, México City, México.
#
Email: juarezol@
Received May 25th, 2012; revised June 29th, 2012; accepted July 5th, 2012
ABSTRACT
Aim: The purpose of this study was to understand the mechanism of nicotine mediated addiction and the role of oli-
goelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and repeated doses
of nicotine and/or oligoelements as follows: group 1 (control) NaCl 0.9%; group 2, nicotine (1 mg/kg); group 3, oli-
goelements (50 µl/rat); and group 4, nicotine (1 mg/kg) + oligoelements (50 µl/rat). All drugs were intraperitoneally
administered for 4 days. Blood for the measurement of
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