原创力文档effects of indole-3-carbinol and flavonoids administered separately and in combination on nitric oxide production and inos expression in rats和类黄酮单独管理和吲哚- 3 -甲醇的影响结合在老鼠体内一氧化氮产量和进气阀打开表达式.pdfVIP
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effects of indole-3-carbinol and flavonoids administered separately and in combination on nitric oxide production and inos expression in rats和类黄酮单独管理和吲哚- 3 -甲醇的影响结合在老鼠体内一氧化氮产量和进气阀打开表达式
Chinese Medicine, 2010, 1, 5-17
doi:10.4236/cm.2010.11002 Published Online June 2010 (http://www.SciRP.org/journal/cm)
Effects of Indole-3-Carbinol and Flavonoids Administered
Separately and in Combination on Nitric Oxide
Production and iNOS Expression in Rats
1 1 2 3 3 1
Evita Rostoka , Larisa Baumane , Sergejs Isajevs , Aija Line , Karina Silina , Maija Dzintare ,
Darja Svirina2 1 1 1,2
, Jelena Sharipova , Ivars Kalvinsh , Nikolajs Sjakste
1
Latvian Institute of Organic Synthesis, Riga, Latvia
2Faculty of Medicine, University of Latvia, Riga, Latvia
3Latvian Biomedical Research and Study Centre, Riga, Latvia
E-mail : Nikolajs.Sjakste@lu.lv
Received January 20, 2010; revised April 29, 2010; accepted May 10, 2010
Abstract
Beneficial effects of natural compounds are often attributed to modulation of NO production; however ef-
fects produced by plant extracts do not correlate with effects of purified components. The goal of our work
was to study ability of flavonoids and indole-3-carbinol, as well as their combinations to modify NO produc-
tion, iNOS gene and protein expression in rat tissues. Baicalein and luteolin decreased NO concentration in
both intact and LPS-treated animals. Baicalein decreased iNOS gene expression. Luteolin decreased NO
production in the liver and heart and number of iNOS-positive cells in the liver of LPS-treated animals.
Combination of the two su
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