原创力文档effects of methacrylic acid on physicalmechanical properties and biocompatibility of urethane-based denture biomaterials甲基丙烯酸的影响对预先属性和urethane-based假牙生物材料的生物相容性.pdfVIP
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effects of methacrylic acid on physicalmechanical properties and biocompatibility of urethane-based denture biomaterials甲基丙烯酸的影响对预先属性和urethane-based假牙生物材料的生物相容性
Materials Sciences and Application, 2011, 2, 1070-1075
doi:10.4236/msa.2011.28144 Published Online August 2011 (http://www.SciRP.org/journal/msa)
Effects of Methacrylic Acid on
Physical/Mechanical Properties and
Biocompatibility of Urethane-Based Denture
Biomaterials
1 1 2 1*
Zhengbing Cao , Xinbo Sun , Chih-Ko Yeh , Yuyu Sun
1Biomedical Engineering Program, University of South Dakota, Sioux Falls, USA; 2 Department of Comprehensive Dentistry, Uni-
versity of Texas Health Science Center at San Antonio and Geriatric Research, Education and Clinical Center, Audie L. Murphy
Division, South Texas Veterans Health Care System, San Antonio, USA.
*
Email: yuyu.sun@
Received May 3rd, 2011; revised June 8th, 2011; accepted June 15th, 2011.
ABSTRACT
Candida-associated denture stomatitis (CADS) is a significant clinical concern. We have demonstrated that ure-
thane-based denture biomaterials with 10% methacrylic acid (MAA) could bind and then slowly release antifungal drug
for months. Drugs on the resins could be repeatedly quenched/recharged , and in subsequent recharging, they could be
changed/switched to more potent/effective ones. However, the physical/mechanical properties and biocompatibility of
the new MAA-based resins are currently unknown. The objective of the current study is to evaluate the effects of co-
polymerization with MAA on physical/mech anical properties and biocompatibility of urethane-based denture resin ma-
terials. MAA and diurethane dimethacrylate (UDMA) were copolymerized using initiator azobisisobutyronitrile (AIBN).
Water sorption and solubility were assessed with the specifications of ISO (International Standards Organization) test
method 1567, flexural strength and modulus were measured according to ASTM D-790, and biocompatibility was pre-
liminarily evaluated in cytotoxicity assay usi
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