effects of metformin on the regulation of free fatty acids in insulin resistance a double-blind, placebo-controlled study二甲双胍对游离脂肪酸的规定的影响胰岛素抵抗双盲,安慰剂对照研究.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2012, Article ID 394623, 7 pages doi:10.1155/2012/394623 Clinical Study Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance: A Double-Blind, Placebo-Controlled Study Manuel Castro Cabezas,1 Jeroen P. H. van Wijk,2 Jan Willem F. Elte,1 and Boudewijn Klop1 1 Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis Rotterdam, P.O. Box 10900, 3004 BA Rotterdam, The Netherlands 2 Department of Internal Medicine, Gelderse Vallei Hospital, P.O. Box 9025, 6710 HN Ede, The Netherlands Correspondence should be addressed to Manuel Castro Cabezas, m.castrocabezas@sfg.nl Received 17 July 2012; Revised 10 September 2012; Accepted 24 September 2012 Academic Editor: Roger A. Fielding Copyright © 2012 Manuel Castro Cabezas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Impaired free fatty acid (FFA) metabolism is closely linked to insulin resistance. Our aim was to evaluate plasma FFA changes in insulin resistance in a physiological situation after improvement of insulin sensitivity by metformin. Methods. A double- blind, placebo-controlled intervention with metformin was carried out in patients with insulin resistance. Nineteen patients were randomized to receive metformin 850 mg b.i.d. during 6 weeks or placebo. Participants underwent a mental stress test and an oral glucose tolerance test (OGTT) before and after treatment. Results. Fasting plasma glucose, FFA, and HOMA-IR tended to decrease after metformin, suggesting improved insulin sensitivity. FFA co