effect of temperature on crossing over in the mus309 mutant, deficient in dna double-strand break repair, of drosophila melanogaster suggests a mechanism for crossover interference温度对交叉mus309突变体,在dna双链断裂修复缺陷,黑腹果蝇表明交叉干扰机制.pdfVIP

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effect of temperature on crossing over in the mus309 mutant, deficient in dna double-strand break repair, of drosophila melanogaster suggests a mechanism for crossover interference温度对交叉mus309突变体,在dna双链断裂修复缺陷,黑腹果蝇表明交叉干扰机制.pdf

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effect of temperature on crossing over in the mus309 mutant, deficient in dna double-strand break repair, of drosophila melanogaster suggests a mechanism for crossover interference温度对交叉mus309突变体,在dna双链断裂修复缺陷,黑腹果蝇表明交叉干扰机制

Open Journal of Genetics, 2011, 1, 38-47 OJGen doi:10.4236/ojgen.2011.13008 Published Online December 2011 (http://www.SciRP.org/journal/ojgen/). Effect of temperature on crossing over in the mus309 mutant, deficient in DNA double-strand break repair, of Drosophila melanogaster suggests a mechanism for crossover interference Petter Portin Laboratory of Genetics, Department of Biology, University of Turku, Turku, Finland. Email: petter.portin@utu.fi Received 16 September 2011; revised 27 October 2011; accepted 19 November 2011. ABSTRACT lication of the chromosomes. Meiosis involves pairing of the homologous chromosomes and, exchange by cross- Crossing-over frequencies, crossover interference, ing over of genetic material between them resulting in recombination frequencies and map distances were the formation of chiasmata. A chiasma is a sufficient compared in the cv-v-f region of the X chromo- condition for the segregation of homologous chromo- some of Drosophila melanogaster in females bearing somes, which leads to the reduction of the chromosome either wild type 3rd chromosomes (control) or hav- number from diploid to haploid. The alternation of mei- ing the DNA double-strand break repair deficient osis and fertilization leads to the recombination of ge- mus309D 2/mus309D3 mutant constitution in the 3rd netic material. chromosomes (experiment), and raised in three dif- An important phenomenon associated with crossing ferent temperatures viz. 18˚C,