青少年肥胖及代谢综合征关系探究.docVIP

青少年肥胖及代谢综合征关系探究【摘要】 目的 分析不同营养状况青少年的脂代谢 、糖代谢和血压状况，研究青少年肥胖与代谢综合征(MS)的关系。方法选择北京市东城区初中生966名，进行身体测量和血压、血 脂、空腹血糖和胰岛素测定。结果 不同营养状况青少年血压(SBP和DBP) 、血脂(TC，TG， LDL-C)和空腹胰岛素(FINS)水平差异均有统计学意义（P值均＜0.05），均随体重指数( BMI)增加而上升；空腹血糖(FPG)差异无统计学意义（P＞0.05）；除FPG，HDL-C外，其 余MS指标异常检出率均为肥胖组超重组体重正常组（P值均＜0.05）。结论 青少年肥胖与MS发生密切相关。肥胖青少年已经出现代谢紊乱，应重视并积极防 治。 【关键词】 肥胖症；代谢综合征X；研究；青少年 【中图分类号】 R 179 R 589.2 【文献标识码】 A 【文章编号】 1000-98 17(2007)10-0878-03 Study on the Relationship Between Obesity and Metabolic Syndrome in Adol escents/WANG Hai-jun?*, MA Jun, YIN Zun-dong, et al. ?* Department o f Maternal and Children Health, School of Public Health, Peking University, Beij ing(100083),China 【Abstract】 Objective To analyze the levels of serum lipids,glucose and blood pressure of adolescents under different nutrition status, in o rder to study the relationship between obesity and metabolic syndrome in adolesc ents. Methods Altogether 966 middle-school students were selec t ed from Dongcheng District, Beijing. Physical examination, blood pressure, serumlipids, fasting glucose and insulin assays were performed for all subjects. ResultsThe levels of blood pressure(SBP and DBP), serum lipids(T C,TG and LDL-C) and fasting insulin (FINS) were different among normal-weight,overweight and obese groups(P＜0.05), increasing along withbody mass index(BMI), while the level of fasting glucose(FPG) not different(P ＞0 .05).Except for FPG, HDL-C, the abnormal rate of other MS indices were differen t among the three groups, obeseoverweightnormal weight(P＜0.05). ConclusionObesity is relevant to metabolic syndrome in adolescents. T here are metabolic syndrome carriers among obese adolescents. More attention sho uld be paid to prevent and treat it. 【Key words】 Obesity;Metabolic syndrome X;Research;Adolescent 随着社会经济的快速发展和生活方式的转变，肥胖已经成为我国学生面临的主要营养问 题。成人肥胖经常伴发高血压、胰岛素抵抗、脂代谢及糖代谢紊乱等，这些疾病聚集现象被 称为代谢综合征(MS)。近年来，越来越多的研究证实，MS多始于儿童期，儿童青少年肥 胖与MS之间存在某种联系，尽管通常不表现出任何临床症状，但这些代谢异常是成年期心血 管疾病发生的重要危险因素［1］。为探讨青少年肥胖与代谢综合征的关系，笔者 采用病例对照研究方法