CEACAM1和VEGF在宫颈鳞癌组织中的表达及临床意义.pdfVIP

· 20· JOURNAL OF BASlC AND CLINlCAL ONCOLOGY V0J．21 No．1 Feb．2o08 CEACAM1和VEGF在宫颈鳞癌组织中的表达及临床意义 吕满义，纪新强，高占军 (青岛大学医学院附属医院妇科，山东 青岛266003) 摘要：目的 研究CEACAM1、VEGF和微血管密度(MVD)在宫颈癌组织中的表达与子宫颈癌的生长、浸润及转移的关系。方法 采用免疫组化二步法检测76例子宫颈鳞癌(高分化22例、中分化25例、低分化29例)，15例宫颈上皮内瘤变(C1N)和10例正常宫 颈组织中CEACAM1、VEGF的表达及 cEAcAM1标记的微血管密度。结果 在宫颈鳞癌组 CEACAM1、VEGF及 CEACAM1标记的 MVD的表达与正常宫颈组织和CIN组差异有统计学意义(P0．05)，并且在宫颈鳞癌中的表达与盆腔淋巴结转移、组织学分级及 FIGO分期有关(P0，05)，而与年龄无关(P0．05)。VEGF在宫颈癌中的表达与 MVD的表达关系密切(P0．01)。结论 CEACAM1是一种肿瘤抑制因子，但其在肿瘤新生血管生成中起促进作用，VEGF可能在CEACAM1促进新生血管形成的过程中起 到协同作用。 关键词：CEACAM1；VEGF；MVD；宫颈癌；肿瘤转移 中图分类号：R737．33 文献标识码：A 文章编号：1673—5412(2o08)01—0020—04 Expressions of CEACAM 1 and VEGF in Cervical Squamous—Cell Carcinomas and Its Clinical Significance ， Lv Manyi，ji Xinqiang，Gao Zhanjun (Department of Obstetrics and Gynecology，the Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China) Abstract：0bjective To observe CEACAM 1 and VEGF and expressions of microvessel density(M VD)in human cervical carcinomas and to clarify their significance in the invision and metastasis of cervical carcinomas．Methods CEACAM1 and VEGF were stained immunohisto- chemically(envision plus)in 76 cases with cervical squamous—cell carcinomas，15 cases with cervical intraepithelial neoplasia(CIN)and 10 cases with nornlal cervices．Results In cervical squamous—cell carcinomas，expressions of CEACAM1，VEGF and MVD were significant— ly higher than those in the cases of CIN and normal cervices(P0．05)．Expressions of CEACAM1，VEGF and MVD had relation to pelvic lymph node metastasis，hist0path0l0gical grading and FIGO staging(P0．05)but had no relation to age(P0．05)．In cervical cancer the MVD was positively correlated with the expressions of VEGF．Conclusions CEACAM 1 may serve as a antitumor b