胰腺β细胞氧化还原状态对胰岛素加工与分泌的调控及其机制.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(10): 1288– 1294 DOI: 10.11844/cj cb.2016.10.0157 β 胰腺 细胞氧化还原状态对胰岛素加工与 分泌的调控及其机制 刘春燕 邓蒙生 郝亚楠 崔华清 刘建辉* (重庆理工大学, 药学与生物工程学院, 重庆400054) β β 摘要 胰腺 细胞的氧化还原异常不仅会引起 细胞凋亡, 而且对胰岛素加工、分泌以及胰 β 岛素抵抗也有重要的影响。近年来, 国内外学者就胰腺 细胞氧化还原状态对胰岛素加工、分泌的 影响及调控机制开展了大量的研究, 取得了丰硕的成果, 为2型糖尿病的防治提供了新思路和靶点。 该文拟就胰岛素加工、分泌与细胞氧化还原状态的关系进行综述, 以期进一步了解、认识2型糖尿 病的发生和发展。 关键词 胰岛素分泌; 氧化还原状态; 2型糖尿病 Mechanism and Regulation of Redox Relativity on the Processing and Secretion of Insulin in Pancreatic β Cells Liu Chunyan, Deng Mengsheng, Hao Yanan, Cui Huaqing, Liu Jianhui* (College of Pharmacy Bioengineering, Chongqing University of Technology, Chongqing 400054, China) Abstract A growing body of evidence suggests that redox imbalance plays an essential role in pancreatic β cells, which does not only induce the cellular apoptosis, but also affects the processing and secretion of insulin. Recently, great progress has been made in understanding the mechanism and regulation of redox balance on the processing of insulin and glucose-stimulated insulin secretion, which supplies some new ideas and targets for the treatment of type 2 diabetes mellitus. Herein, we try to summarize the development about the effects of redox state on the processing and secretion of insulin, and as for a further comments to understand the formation and development of type 2 diabetes mellitus. Keywords insulin secretion; redox state; type 2 diabetes mellitus 2014年3月, 《柳叶刀》杂志上发表了DNA双螺 病、心血管疾病以及某些癌症的发生和发展的作