麻风-地奈德乳膏联合他扎罗汀乳膏治疗寻常型斑块性银屑病的疗效观察.docVIP

他扎罗汀凝胶和地奈德乳膏联合治疗寻常型斑块性银屑病的疗效观察 Efficacy of combination Tazarotene Gel with Desonide Cream in the Treatment of Plaque psoriasis 谢震，杨建文，林昭春 [摘要] 目的 观察他扎罗汀凝胶和地奈德乳膏联合治疗斑块性银屑病的疗效。方法 将84例患者随机平均分入联合治疗组和两个单药对照组，联合组晚上外用1次他扎罗汀，早上再用1次地奈德乳膏。地奈德组单用地奈德乳膏，每天2次，他扎罗汀组则仅晚上外用1次他扎罗汀，疗程均为4周。结果 治疗斑块性银屑病的总有效率为64.3%，观察期间未发生严重不良反应。结论 他扎罗汀联合地奈德治疗斑块性银屑病等效于地奈德单用但优于他扎罗汀单用，而复发率和不良反应发生率更低。 [关键词] 他扎罗汀；地奈德；银屑病；联合 Efficacy of combination Tazarotene Gel with Desonide Cream in the Treatment of Plaque psoriasis XIE Zhen, YANG Jian-wen, LIN Zhao-chun [Abstract] Objective To evaluate the efficacy of a combination therapy with tazarotene gel and desonide cream in plaque psoriasis. Methods 84 patients were randomly assigned into combination treatment group and two solo treatment groups. In the combination group, tazarotene gel was applied 1 time per day at night and desonide cream was applied 1 time per day in the morning. In the desonide solo treatment groups, desonide cream was applied twice a day and in the tazarotene sole group, the gel was applied 1 time per day at night. Results The total efficacy rate for combination group was 64.3. There is not any serious adverse event happened during the investigation.. Conclusions the efficacy of the combination therapy was equal to desonide sole but supassed the tazarotene solo treatment, meanwhile the recurrence rate and incidence of adverse event were lower than the two solo groups. Key words: tazarotene; desonide; psoriasis; combination 银屑病是一种慢性、复发性皮肤病，尚无完全治愈的方法，在各类型银屑病中以寻常型最为常见，而此型中又尤以斑块性的治疗相对较难，目前治疗仍以激素软膏为主，但单用激素不良反应多，且停药后易复发。我们用他扎罗汀凝胶（重庆华邦股份有限公司）联合地奈德乳膏治疗寻常型斑块状银屑病28例，并与单用地奈德乳膏(重庆华邦股份有限公司)和单用他扎罗汀凝胶相比较，现报道如下： 资料和方法： 1.1 一般资料 所有入选病例均为2008年4月至2008年10月本科的门诊患者，确诊为寻常型斑块性银屑病，年龄在16岁以上，性别不限，同意并坚持治疗方案，一共84例，随机分成3组。他扎罗汀和地奈德联合治疗组28例，男18例，女10例；平均年龄38.2（22-53）岁；平均病程23.4（8-60）月；地奈德组28例，其中男13例，女15例，平均年龄38.9（25-62）岁,平均病程21.6（5-76）月;他扎罗汀组28例，其中男15例，女18例，平均年龄42.8（24-74）岁，平均病程21.5（6-67）岁。排除标准为:4周内未系统使用过维A酸类药物、糖皮质激素及免疫抑制剂;4周内使用过补骨脂素长波紫(PUVA);2周内使用过中波紫外线(UVB)及其它局部治疗;对他扎罗汀或地奈