原创力文档acute and chronic administrations of rheum palmatum reduced the bioavailability of phenytoin in rats a new herb-drug interaction急性和慢性的政府感冒palmatum苯妥英的生物利用度,减少老鼠一个新的herb-drug交互.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
acute and chronic administrations of rheum palmatum reduced the bioavailability of phenytoin in rats a new herb-drug interaction急性和慢性的政府感冒palmatum苯妥英的生物利用度,减少老鼠一个新的herb-drug交互
Hindawi Publishing Corporation
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 701205, 9 pages
doi:10.1155/2012/701205
Research Article
Acute and Chronic Administrations of
Rheum palmatum Reduced the Bioavailability of
Phenytoin in Rats: A New Herb-Drug Interaction
Ying-Chang Chi,1 Shin-Hun Juang,1 Wai Keung Chui,2
Yu-Chi Hou,3, 4 and Pei-Dawn Lee Chao3
1 Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan
2 Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543
3 School of Pharmacy, China Medical University, Taichung 40402, Taiwan
4 Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan
Correspondence should be addressed to Yu-Chi Hou, hou5133@ and Pei-Dawn Lee Chao,
Received 16 March 2012; Revised 23 April 2012; Accepted 27 April 2012
Academic Editor: Paul Siu-Po Ip
Copyright © 2012 Ying-Chang Chi et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
The rhizome of Rheum palmatum (RP) is a commonly used herb in clinical Chinese medicine. Phenytoin (PHT) is an antiepileptic
with narrow therapeutic window. This study investigated the acute and chronic effects of RP on the pharmacokinetics of PHT in
rat. Rats were orally administered with PHT (200 mg/kg) with and without RP decoction (single dose and seven doses of 2 g/kg)
in a crossover design. The serum concentrations of PHT, PHT glucuronide (PHT-G), 4-hydroxyphenytoin (HPPH), and HPPH
glucuronide (HPPH-G) were determined by HPLC method. Cell line models were us
您可能关注的文档
- a versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs一种多功能聚合物胶束药物输送系统封装和疏水性抗癌药物的体内稳定.pdf
- a video specific instruction set architecture for asip design一个视频的具体指令集架构asip设计.pdf
- a wake model for the prediction of propeller performance at low advance ratios后模型的预测螺旋桨性能较低的比率.pdf
- a woman with a lower lip nodule what is your diagnosis一个女人嘴唇结节较低你的诊断.pdf
- abdominal adiposity correlates with adenotonsillectomy outcome in obese adolescents with severe obstructive sleep apnea结果接受腹部肥胖与腺样扁桃体切除术在肥胖青少年严重的阻塞性睡眠呼吸暂停.pdf
- a wide lock-range referenceless cdr with automatic frequency acquisition大锁范围referenceless cdr自动频率采集.pdf
- a wireless sensor network system with a jumping node for unfriendly environments无线传感器网络系统与跳节点为不友好的环境.pdf
- abnormal gastroscopy findings were related to lower meridian energy胃镜检查发现异常相关经络能量低.pdf
- abnormal leg muscle latencies and relationship to dyscoordination and walking disability after stroke腿部肌肉延迟和异常关系dyscoordination和卒中后残疾行走.pdf
- abnormalities of the first three steps of gait initiation in patients with parkinson's disease with freezing of gait前三个步骤的异常步态起始帕金森氏症患者步态的冻结.pdf
- acupuncture on the endometrial morphology, the serum estradiol and progesterone levels, and the expression of endometrial leukaemia-inhibitor factor and osteopontin in rats针灸在子宫内膜形态、血清雌二醇和孕酮水平,在大鼠子宫内膜leukaemia-inhibitor因子和骨桥蛋白的表达.pdf
- acute hyperglycemia does not impair microvascular reactivity and endothelial function during hyperinsulinemic isoglycemic and hyperglycemic clamp in type 1 diabetic patients急性高血糖不损害微血管反应和内皮功能在血糖isoglycemic和高血糖的夹在1型糖尿病患者.pdf
- acute kidney injury in adpkd patients with pneumonia急性肾损伤在adpkd患者肺炎.pdf
- acute and 28-day subchronic oral toxicity of an ethanol extract of zingiber zerumbet (l.) smith in rodents急性和28天subchronic口服毒性的乙醇提取姜zerumbet(l).pdf
- acute renal replacement therapy in pediatrics在儿科急性肾脏替代治疗.pdf
- acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient急性肾功能衰竭、microangiopathic溶血性贫血和二级oxalosis年轻的女病人.pdf
- acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome a single center 16 years of experience急性肾脏替代疗法在儿童diarrhea-associated溶血性尿毒症综合征单一中心16年的经验.pdf
- acute-phase serum amyloid a as a marker of insulin resistance in mice急性期血清淀粉样蛋白小鼠胰岛素抵抗的标志.pdf
- acu-tens and postexercise expiratory flow volume in healthy subjectsacu-tens并在健康受试者运动后呼气流量.pdf
- acylated 2-(n-arylaminomethylene)benzo[b]thiophene-3(2h)-ones molecular switches with varying migrants and substituentsacylated 2 -(n-arylaminomethylene)苯并[b]thiophene-3(2 h)的分子开关取代基不同移民和.pdf
文档评论（0）