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antineuropathic and antinociceptive drugs combination in patients with chronic low back pain a systematic reviewantineuropathic和antinociceptive药物组合在慢性下腰痛患者系统回顾
Hindawi Publishing Corporation
Pain Research and Treatment
Volume 2012, Article ID 154781, 8 pages
doi:10.1155/2012/154781
Review Article
Antineuropathic and Antinociceptive Drugs Combination in
Patients with Chronic Low Back Pain: A Systematic Review
` 1 ` 1 2
Carlo Luca Romano, Delia Romano, and Marco Lacerenza
1 Centro di Chirurgia Ricostruttiva, Istituto Ortopedico I.R.C.C.S. Galeazzi, Via R. Galeazzi 4, 20161 Milano, Italy
2 Centro di Medicina del Dolore, Casa di cura S. Pio X, Fondazione Opera San Camillo, Via F. Nava 31, 20159 Milano, Italy
`
Correspondence should be addressed to Carlo Luca Romano, carlo.romano@grupposandonato.it
Received 8 January 2012; Revised 4 February 2012; Accepted 8 February 2012
Academic Editor: Young-Chang P. Arai
`
Copyright © 2012 Carlo Luca Romano et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Purpose. Chronic low back pain (LBP) is often characterized by both nociceptive and neuropathic components. While various
monotherapies have been reported of only limited efficacy, combining drugs with different mechanisms of action and targets
appears a rational approach. Aim of this systematic review is to assess the efficacy and safety of different combined pharmacological
treatments, compared to monotherapy or placebo, for the pharmacological treatment of chronic LBP. Methods. Published papers,
written or abstracted in English from 1990 through
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