antinociceptive activity of trichilia catigua hydroalcoholic extract new evidence on its dopaminergic effectsantinociceptive活动trichilia catigua hydroalcoholic提取新证据的多巴胺能的影响.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 120820, 8 pages doi:10.1093/ecam/nep144 Original Article Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects Alice F. Viana,1, 2 Izaque S. Maciel,2 Emerson M. Motta,1 Paulo C. Leal,3 4 5 ˜ 1 Luiz Pianowski, Maria M. Campos, and Joao B. Calixto 1 Department of Pharmacology, Universidade Federal de Santa Catarina, Campus Universit´ario, Trindade, Florian´opolis, SC, Brazil 2 Faculty of Pharmacy, Pontif´ıcia Universidade Cat´olica do Rio Grande do Sul, Porto Alegre, RS, Brazil 3 Department of Chemistry, Universidade Federal de Santa Catarina, Campus Universit´ario, Trindade, Florian´opolis, SC, Brazil 4 Pianowski and Pianowski Consulting, Brazil 5 Faculty of Dentistry, Pontif´ıcia Universidade Cat´olica do Rio Grande do Sul, Porto Alegre, RS, Brazil ˜ Correspondence should be addressed to Joao B. Calixto, calixto@farmaco.ufsc.br Received 7 February 2009; Accepted 29 August 2009 Copyright © 2011 Alice F. Viana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Trichilia catigua is a native plant of Brazil; its barks are used by some local pharmaceutical companies to prepare tonic drinks, such as Catuama. The present study was addressed to evaluate the effects of T. catigua hydroalcoholic extract in mouse nociception behavioral models, and to evaluate the possible mechanisms involved in its acti