association of mica alleles with autoimmune thyroid disease in korean children协会的云母等位基因与自身免疫性甲状腺疾病在韩国的孩子.pdfVIP

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association of mica alleles with autoimmune thyroid disease in korean children协会的云母等位基因与自身免疫性甲状腺疾病在韩国的孩子.pdf

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association of mica alleles with autoimmune thyroid disease in korean children协会的云母等位基因与自身免疫性甲状腺疾病在韩国的孩子

Hindawi Publishing Corporation International Journal of Endocrinology Volume 2012, Article ID 235680, 7 pages doi:10.1155/2012/235680 Clinical Study Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children Won Kyoung Cho,1 Min Ho Jung,1 So Hyun Park,1 In Cheol Baek,2 Hee-Baeg Choi,3 Tai-Gyu Kim,2, 3 and Byung-Kyu Suh1 1 Department of Pediatrics, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of Korea 2 Department of Microbiology, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of Korea 3 Catholic Hematopoietic Stem Cell Bank, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of Korea Correspondence should be addressed to Tai-Gyu Kim, kimtg@catholic.ac.kr and Byung-Kyu Suh, suhbk@catholic.ac.kr Received 7 August 2012; Revised 19 October 2012; Accepted 20 October 2012 Academic Editor: Ajai Kumar Srivastav Copyright © 2012 Won Kyoung Cho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 7