association of plasma homocysteine with self-reported sleep apnea is confounded by age results from the national health and nutrition examination survey 2005-2006协会血浆同型半胱氨酸与自我报告的睡眠呼吸暂停是困惑的年龄结果2005 - 2006年全国健康和营养调查.pdfVIP
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association of plasma homocysteine with self-reported sleep apnea is confounded by age results from the national health and nutrition examination survey 2005-2006协会血浆同型半胱氨酸与自我报告的睡眠呼吸暂停是困惑的年龄结果2005 - 2006年全国健康和营养调查
Hindawi Publishing Corporation
Sleep Disorders
Volume 2012, Article ID 634920, 9 pages
doi:10.1155/2012/634920
Research Article
Association of Plasma Homocysteine with Self-Reported
Sleep Apnea Is Confounded by Age: Results from the National
Health and Nutrition Examination Survey 2005-2006
Tushar P. Thakre,1, 2 Manju Mamtani,1 Shweta Ujaoney,1, 3 and Hemant Kulkarni1, 4
1 Lata Medical Research Foundation, Nagpur, 440022, India
2 Cleveland Clinic Sleep Disorders Center, Cleveland, OH 44195, USA
3 Advanced Education in General Dentistry program, Case School of Dental Medicine, Cleveland, OH 44206, USA
4 Texas Biomedical Research Institute, San Antonio, TX 78227-5301, USA
Correspondence should be addressed to Hemant Kulkarni, hemant kulkarnius@
Received 15 October 2011; Revised 10 November 2011; Accepted 14 November 2011
Academic Editor: Sophia Schiza
Copyright © 2012 Tushar P. Thakre et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
High levels of plasma homocysteine are implicated in the pathogenesis of cardiovascular diseases especially if accompanied
by sleep apnea, but a direct pathogenetic link between plasma homocysteine levels and obstructive sleep apnea is debatable.
This association can have far-reaching public health implications considering the inverse association between folate and plasma
homocysteine. We used data from the 2005-2006 cycle of the National Health and Nutrition Examination Survey (NHANES)
to test the hypothesized associations. Of the 4490 subjects included in analysis, 177 reported sleep apnea. Age-standardized and
desig
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