renal transplantation in hepatitis c positive patients a single centre experience丙型肝炎病毒阳性患者的肾移植一个中心体验.pdf

Hindawi Publishing Corporation Journal of Transplantation Volume 2011, Article ID 581485, 5 pages doi:10.1155/2011/581485 Clinical Study Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience P. R. Shah,1 A. V. Vanikar,2 M. R. Gumber,1 H. V. Patel,1 V. B. Kute,1 S. M. Godara,1 and H. L. Trivedi1 1 Department of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, India 2 Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, IKDRC-ITS, Ahmedabad 380016, India Correspondence should be addressed to P. R. Shah, drpankajrshah@ Received 23 March 2011; Revised 25 July 2011; Accepted 13 September 2011 ¨ Academic Editor: Bernhard K. Kramer Copyright © 2011 P. R. Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. Methods. We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation. Their immunosuppression was cyclosporin, 2 ± 1 mg/kgBW/day + prednisone, 10 mg/day. Results. TIP had no side effects. Although unequal in size, the groups were well balanced. Group A patient survival at 1, 5, and 10 years was 92