repeated intraperitoneal -radioimmunotherapy of ovarian cancer in mice卵巢癌腹腔放射小鼠重复.pdf

Hindawi Publishing Corporation Journal of Oncology Volume 2010, Article ID 394913, 5 pages doi:10.1155/2010/394913 Research Article Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in Mice ¨ 1 ˚ 1 2 1 1 Jorgen Elgqvist, Hakan Andersson, Holger Jensen, Helena Kahu, Sture Lindegren, Elisabet Warnhammar,1 and Ragnar Hultborn1 1 Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden 2 PET and Cyclotron Unit, Rigshospitalet, Copenhagen, Denmark ¨ Correspondence should be addressed to Jorgen Elgqvist, jorgen.elgqvist@gu.se Received 15 April 2009; Accepted 1 September 2009 Academic Editor: Maurie M. Markman ¨ Copyright © 2010 Jorgen Elgqvist et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study was to investigate the therapeutic efficacy of α-radioimmunotherapy of ovarian cancer in mice using different fractionated treatment regimens. The study was performed using the monoclonal antibody MX35 F(ab )2 labeled with the α- particle emitter 211At. Methods. Nude mice were intraperitoneally inoculated with ∼1 × 107 cells of the cell line NIH:OVCAR-3. 211 Four weeks later 6 groups of animals were given 400 kBq At-MX35 F(ab )2 as a single or as a repeated treatment of up to 6 times (n