repertoire development and the control of cytotoxiceffector function in human t cells曲目的控制开发和cytotoxiceffector人类t细胞功能.pdf

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 732893, 11 pages doi:10.1155/2010/732893 Review Article Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells Elizabeth M. Urban,1 Andrei I. Chapoval,2 and C. David Pauza1 1 Institute of Human Virology, University of Maryland, School of Medicine, 725 W. Lombard Street, Baltimore, MD 21201, USA 2 Department of Otorhinolaryngology, University of Maryland, School of Medicine, 725 W. Lombard Street, Baltimore, MD 21201, USA Correspondence should be addressed to C. David Pauza, cdpauza@ Received 9 October 2009; Accepted 16 February 2010 Academic Editor: Ethan Shevach Copyright © 2010 Elizabeth M. Urban et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the αβ TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate γδ TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens. We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on γδ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells. A unique mechanism for MHC-independent repertoire selection is linked to the