repeated physical training and environmental enrichment induce neurogenesis and synaptogenesis following neuronal injury in an inducible mouse model重复的体能训练和环境富集诱导神经发生及神经损伤后突触发生诱导小鼠模型.pdf

Journal of Behavioral and Brain Science, 2011, 1, 199-209 doi:10.4236/jbbs.2011.14027 Published Online November 2011 (http://www.SciRP.org/journal/jbbs) Repeated Physical Training and Environmental Enrichment Induce Neurogenesis and Synaptogenesis Following Neuronal Injury in an Inducible Mouse Model † †* Fabiana Morroni , Masashi Kitazawa , Denise Drago, David Cheng, * Rodrigo Medeiros, Frank M. LaFerla Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA * * E-mail : kitazawa@, laferla@ Received July 19, 2011; revised August 20, 2011; accepted September 5, 2011 Abstract Neuronal loss as a consequence of brain injury, stroke and neurodegenerative disorders causes functional impairments ranging from cognitive impairments to physical disabilities. Extensive rehabilitation and train- ing may lead to neuroprotection and promote functional recovery, although little is known about the molecu- lar and cellular mechanisms driving this event. To investigate the underlying mechanisms and levels of func- tional recovery elicited by repeated physical training or environmental enrichment, we generated an induc- ible mouse model of selective CA1 hippocampal neuronal loss. Following the CA1 neuronal injury, mice underwent one of the above mentioned conditions for 3 months. Exposure to either of these stimuli promoted functional cognitive recovery, which was associated with increased