serum adipokine and ghrelin levels in nonalcoholic steatohepatitis在非酒精性脂肪肝炎血清adipokine和胃促生长素水平.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2006, Article ID 34295, Pages 1–5 DOI 10.1155/MI/2006/34295 Research Communication Serum Adipokine and Ghrelin Levels in Nonalcoholic Steatohepatitis Mehmet Yalniz,1 Ibrahim Halil Bahcecioglu,1 Huseyin Ataseven,1 Bilal Ustundag,2 Fulya Ilhan,3 Orhan K. Poyrazoglu,1 and Ahmet Erensoy4 1 Department of Gastroenterology, School of Medicine, Firat University, 23200 Elazig, Turkey 2 Department of Biochemistry, School of Medicine, Firat University, 23200 Elazig, Turkey 3 Department of Immunology, School of Medicine, Firat University, 23200 Elazig, Turkey 4 Department of Microbiology, School of Medicine, Firat University, 23200 Elazig, Turkey Received 22 May 2006; Revised 23 August 2006; Accepted 23 August 2006 Adipokines and ghrelin play role in insulin resistance, the key pathophysiological abnormality in patients with nonalcoholic fatty liver diseases. In the present study, relationship between nonalcoholic steatohepatitis (NASH) and serum adipokine and ghrelin levels was investigated. Thirty seven patients with biopsy-proven NASH and 25 age- and sex-matched controls were enrolled. Ten of NASH patients (27%) had diabetes mellitus (n = 5) or impaired glucose tolerance (n = 5). Body mass index (BMI) was less 2 2 than 30 kg/m in 67.6% of patients, while in the remaining 32.4% it was more than 30 kg/m . Serum adiponectin, leptin, TNF- α, and ghrelin were determined. Serum leptin (15.49 ± 4.84 vs 10.31 ± 2.53) and TNF-α (12.1 ± 2.7 vs 10.31 ± 2.56) levels were significantly higher in the NASH group compared to in the control group (P .001 for each). Nevertheless, adiponectin (11.1±2.1 vs 17.3 ±2.8) and ghrelin (