the effect of an aqueous extract of teucrium polium on glutathione homeostasis in vitro a possible mechanism of its hepatoprotectant action的影响的水提物teucrium polium在谷胱甘肽在体外体内平衡hepatoprotectant行动的可能机制.pdfVIP

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the effect of an aqueous extract of teucrium polium on glutathione homeostasis in vitro a possible mechanism of its hepatoprotectant action的影响的水提物teucrium polium在谷胱甘肽在体外体内平衡hepatoprotectant行动的可能机制.pdf

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the effect of an aqueous extract of teucrium polium on glutathione homeostasis in vitro a possible mechanism of its hepatoprotectant action的影响的水提物teucrium polium在谷胱甘肽在体外体内平衡hepatoprotectant行动的可能机制

Hindawi Publishing Corporation Advances in Pharmacological Sciences Volume 2010, Article ID 938324, 7 pages doi:10.1155/2010/938324 Research Article The Effect of an Aqueous Extract of Teucrium polium on Glutathione Homeostasis In Vitro: A Possible Mechanism of Its Hepatoprotectant Action Stella Shtukmaster, Predrag Ljubuncic, and Arieh Bomzon Department of Pharmacology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel Correspondence should be addressed to Arieh Bomzon, arieh.bomzon@ Received 8 June 2009; Revised 25 November 2009; Accepted 15 January 2010 Academic Editor: Chun Guang Li Copyright © 2010 Stella Shtukmaster et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Teucrium polium is used in Arab traditional medicine to treat liver diseases. Glutathione is an important intracellular antioxidant, and intrahepatic glutathione levels are depleted in liver diseases. Hypothesis and Aim. This investigation tested the hypothesis that aqueous extracts of T. polium maintains intracellular glutathione levels by augmenting glutathione peroxidase and glutathione reductase activity in cultured hepatocytes. Methods. The eﬀects of increasing concentrations (0.01–1 mg/mL) of aqueous extract of T. polium were assessed in cultured HepG2 cells following 24 hours incubation on (1) cellular integrity using (a) the Trypan blue exclusion assay, (b) the [di-methylthiazol-2yl]-2,5-diphenyl-tetrazoliumbromide (MTT) assay, and (c) the lactate dehydrogenase (LDH) assay; (2) glutathione redox state; and (3) glutathione peroxidas