the effect of conventional and mini-invasive cardiopulmonary bypass on neutrophil activation in patients undergoing coronary artery bypass grafting传统的影响以及mini-invasive心肺旁路在接受冠状动脉旁路移植术的患者中性粒细胞的激活.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 152895, 8 pages doi:10.1155/2012/152895 Clinical Study The Effect of Conventional and Mini-Invasive Cardiopulmonary Bypass on Neutrophil Activation in Patients Undergoing Coronary Artery Bypass Grafting Martina Kolackova,1 Jan Krejsek,1 Vladimir Svitek,2 Pavel Kunes,2 Jiri Mandak,2 Zdenka Holubcova,2 and Vladimir Lonsky2 1 Department of Clinical Immunology, Faculty of Medicine, Charles University, 50005 Hradec Kralove, Czech Republic 2 Department of Cardiac Surgery, University Hospital, 50005 Hradec Kralove, Czech Republic Correspondence should be addressed to Martina Kolackova, kolackovam@lfhk.cuni.cz Received 30 June 2011; Accepted 14 November 2011 Academic Editor: Loek Leenen Copyright © 2012 Martina Kolackova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Interleukin-10 (IL-10) is considered to be a cytokine with potent anti-inflammatory properties, which have been previously linked to increased incidence of sepsis. The level of IL-10 is elevated by cardiac surgery when cardiopulmonary bypass (CPB) and methylprednisolone are used. In our study, we compare the level of IL-10, IL-10 Receptor (IL-10R), and percentage of neutrophils between two groups of cardiac surgical patients undergoing Coronary Artery Bypass Grafting, both of which were not given methylprednisolone. The first group was operated with conventional CPB, while the second group was operated with minimally invasive CPB (mini-CPB). We detected enhanced level of IL-10 during surgery and at the end of surgery in both groups of pa