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transcriptional activity of human epidermal growth factor receptor family and angiogenesis effectors in locoregionally recurrent head and neck squamous cell carcinoma and correlation with patient outcome英文论文.pdf

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transcriptional activity of human epidermal growth factor receptor family and angiogenesis effectors in locoregionally recurrent head and neck squamous cell carcinoma and correlation with patient outcome英文论文

Hindawi Publishing Corporation Journal of Oncology Volume 2009, Article ID 854127, 10 pages doi:10.1155/2009/854127 Research Article Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient Outcome George Pentheroudakis,1 Nikolaos Angouridakis,2 Ralph Wirtz,3 Angelos Nikolaou,2 Konstantine T. Kalogeras,4, 5 Nicholas Pavlidis,1 and George Fountzilas5 1 Department of Medical Oncology, Ioannina University Hospital, Ioannina 45500, Greece 2 ENT Department, “AHEPA” Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki 57100, Greece 3 Siemens Healthcare Diagnostics, Cologne, Germany 4 Hellenic Cooperative Oncology Group, Data Oﬃ ce, Athens 45118, Greece 5 Department of Medical Oncology, “Papageorgiou” Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki 57100, Greece Correspondence should be addressed to George Pentheroudakis, gpenther@otenet.gr Received 7 February 2009; Revised 11 June 2009; Accepted 23 July 2009 Recommended by Amanda Psyrri Locoregional recurrence is the most common failure pattern in patients with head and neck squamous cell carcinoma (HNSCC). We retrospectively identiﬁed 41 HNSCC patients with locoregional relapse and used kinetic reverse transcription-polymerase chain reaction (kRT-PCR) in order to study fresh-frozen tumour messenger RNA (mRNA) levels of the Human Epidermal growth factor family members HER1-4, the Vascular Endothelial Growth Factors (VEGFs) A, B, C, D, and their receptors VEGFR1, 2, 3. High VEGF-C and VEGFR3 tumour mRNA expression correlated with relapse beyond the primary locus (neck nodes or soft tissues, P .05). Tumours with reg