厄洛替尼在Lewis肺癌小鼠时辰药代动力学特点及相关代谢酶昼夜节律性的的分析研究.pdfVIP

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厄洛替尼在Lewis肺癌小鼠时辰药代动力学特点及相关代谢酶昼夜节律性的的分析研究.pdf

ABSTRACT Objective The ofthecurrentwasto theeffectofthe time purpose study investigate dosing onthe oferlofinibandthecircadian ofthemetabolism pharmacokinetics rhythms thatare forthemetabolismoferlotinibin mice. enzymesresponsible tumor-bearing Methods 1.FemaleC57BLmicewerecontainedunderstandardized12hlight/dark circadian was 19:00-7:00Wasdark conditions(7:0

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