神经元特异性烯醇化酶及急性脑梗死关系探析.docVIP

神经元特异性烯醇化酶及急性脑梗死关系探析[摘要] 目的：探讨神经元特异性烯醇化酶（NSE）检测在急性脑梗死中的临床意义。方法：应用ELISA法检测600例急性脑梗死患者NSE的水平变化，并与正常体检者进行对比分析。结果：脑梗死患者急性期NSE的水平显著高于健康对照组，NSE的水平与脑梗死的严重程度呈正相关。结论：急性脑梗死患者血清NSE水平增高与神经元坏死有关，其水平的高低与中枢神经系统受损程度呈正相关，可作为评估预后的重要参数。 [关键词] 脑梗死；神经元特异性烯醇化酶；预后评估；急性 [中图分类号] R743.33[文献标识码]A[文章编号]1674-4721（2011）04（a）-031-02 The nerve basic peculiarity alkene alcoholization enzyme and impatient brain infarction relation are discussed ZHANG Yong, PAN Jinbao, ZHOU Zhonghua, FU Yuanyuan Department of Neurology, Second People′s Hospital of Yueyang City, Hunan Province, Yueyang 414000, China [Abstract] Objective: To investigation and discussion the nerve basic peculiarity alkene alcoholization enzyme (NSE) checks clinical significance in being in the impatient brain infarction. Methods: ELISA applying follows the horizontal change checking 600 impatient regular brain infarctions patient NSE, and person carries out comparative analysis with regular physical examination. Results: The horizontal notable impatient brain infarction patient scheduled time NSE order of severity higher than healthy collation group, the NSE level and brain infarction memorial was being related to. Conclusion: Impatient brain infarction patient serum NSE is horizontal increase height being connected with nerve basic necrosis, it’s horizontal height and central nervous system is assumed being related to, but is the parameter appraising the prognosis importance by mean degree. [Key words]Brain infarction; Nerve basic peculiarity alkene alcoholization enzyme; The prognosis is appraised; Acute 脑卒中是全球人口死亡和致残的重要原因，而急性脑梗死患者中进展性缺血性脑卒中发病率较高。近年来，脑梗死后释放出来的活性物质引起国内外学者的一致关注，为探讨神经元特异性烯醇化酶（neuron-specific enolase，NSE）检测在急性脑梗死中的临床意义。2008年1月～2010年8月，笔者对岳阳市二医院神经内科600例急性脑梗死患者进行了NSE检查，现就其研究结果分析报道如下： 1 资料与方法 1.1 一般资料 本组共600例患者，男346例，女254例，年龄48～77岁，平均64岁；所有患者均于发病12 h内入院，系首次发病，均符合全国第四届脑血管病学术会议的诊断标准，并经脑CT或MRI证实为血栓性脑梗死，排除脑出血、脑肿瘤、脑外伤及严重的心、肝、肺、肾疾病，伴自身免疫性疾病或肿瘤以及近期有感染的患者。患者入院后根据神经功能缺损评分（NIHSS）的变化，分为进展性缺血性脑卒中和非进展性缺血性