舒利迭联合无创通气抢救老年性慢阻肺呼吸衰竭患者疗效观察.docVIP

舒利迭联合无创通气抢救老年性慢阻肺呼吸衰竭患者疗效观察【摘要】目的：探讨舒利迭联合无创通气在抢救老年性慢阻肺呼吸衰竭患者中的临床疗效。方法：对36例入选患者，按不同的治疗方案随机分入观察组和对照组，观察组给予Esprit呼吸机辅助呼吸，同时通气过程中给予舒利迭雾化吸入，对照组给予Esprit呼吸机辅助呼吸，两组患者均治疗72小时后观察分析治疗前后RR、HR、PaO2、PaCO2、pH的变化以评价其疗效。结果：观察组治疗72小时后RR、HR、PaO2、PaCO2、pH均较治疗前有明显改变，差异有统计学意义（P﹤0.05），观察组治疗后上述指标的变化与对照组比较，改善更显著，差异有统计学意义（P﹤0.05），对照组的上述指标与治疗前比较无显著差异（P﹥0.05）。结论：舒利迭联合无创通气在抢救老年性慢阻肺呼吸衰竭中有较好的疗效，值得推广。 【关键词】：舒利迭 无创通气 慢阻肺 呼吸衰竭 The efficacy of Seretide joint noninvasive ventilation in the treatment of senile COPD patients with respiratory failure Tang ya-lan(Department of Respiratory Medicine ,the people hospital of An Yue , SiChuan 642350 ) ABSTRACT: Objective: To explore the efficacy of the Seretide joint noninvasive ventilation in the treatment of senile COPD patients with respiratory failure. Methods: 36 cases were randomly divided into different regimens of observation group and the control group. The observation group was given the Esprit ventilator-assisted breathing, given seretide inhalation ventilation process; the control group was given the Esprit ventilator-assisted breathing, the analysis of RR, HR, PaO2, PaCO2, and pH showed its efficacy after 72 hours treatment. Result: The RR, HR, PaO2, PaCO2, and pH show significant changes compared with pre-treatment, the difference was statistically significantly(P﹤0.05);the above indicators of changes in the observation group after treatment improved more significantly(P﹤0.05); the changes was no significant difference in control group compared with pre-treatment (P﹥0.05). Conclusion: The Seretide joint noninvasive ventilation in the treatment of senile COPD patients with respiratory failure has a good effect, worth promoting. Key Words: Seretide; Noninvasive ventilation; COPD; Respiratory failure; 舒利迭（沙美特罗替卡松）含有沙美特罗和丙酸氟替卡松，分别为长效β2受体激动剂和肺内强效的糖皮质激素，经气雾剂给药后30分钟起效，并产生至少持续12小时的支气管扩张作用。近年来，国内外的大力研究充分表明，舒利迭对慢性阻塞性肺疾病（chronic obstructive pulmonary diseases，COPD）有肯定的疗效[1, 2]。机械通气是抢救治疗呼吸衰竭的重要治疗方法之一，无创通气指经鼻面罩或口面罩等无创方式连接患者于呼吸机进行的进行通气，因为该方法操作方便，