antifungal activity of resveratrol against botrytis cinerea is improved using 2-furyl derivatives抗真菌活性的提高白藜芦醇对葡萄孢菌使用2-furyl衍生品.pdfVIP

Antifungal Activity of Resveratrol against Botrytis cinerea Is Improved Using 2-Furyl Derivatives 1 2 2 2 2 Francesco Caruso *, Leonora Mendoza , Paulo Castro , Milena Cotoras , Maria Aguirre , Betty 2 3 4 5 1 Matsuhiro , Mauricio Isaacs , Miriam Rossi *, Angela Viglianti , Roberto Antonioletti ´ ´ 1 Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, University of Rome, Istituto Chimico, Rome, Italy, 2 Facultad de Quımica y Biologıa, Universidad de ´ Santiago de Chile, Santiago, Chile, 3 Facultad de Ciencias, Departamento de Quımica, Universidad de Chile, Santiago, Chile, 4 Vassar College, Department of Chemistry, Poughkeepsie, New York, United States of America, 5 University of Rome, Istituto Chimico, Rome, Italy Abstract The antifungal effect of three furyl compounds closely related to resveratrol, (E)-3,4,5-trimethoxy- b-(2-furyl)-styrene (1), (E)- 4-methoxy-b-(2-furyl)-styrene (2) and (E)-3,5-dimethoxy-b-(2-furyl)-styrene (3) against Botrytis cinerea was analyzed. The inhibitory effect, at 100 mg ml21 of compounds 1, 2, 3 and resveratrol on conidia germination, was determined to be about 70%, while at the same concentration pterostilbene (a dimethoxyl derivative of resveratrol) produced complete inhibition. The title compounds were more fungitoxic towards in vitro mycelial growth than resveratrol and pterostilbene. Compound 3 was the most active and a potential explanatio