atmospheric pressure plasma a high-performance tool for the efficient removal of biofilms大气压等离子体的高性能工具的有效去除生物膜.pdfVIP

Atmospheric Pressure Plasma: A High-Performance Tool for the Efficient Removal of Biofilms 1 2 1,3 2 ¨ 1 4 Katja Fricke *, Ina Koban , Helena Tresp , Lukasz Jablonowski , Karsten Schroder , Axel Kramer , 1 1 2 Klaus-Dieter Weltmann , Thomas von Woedtke , Thomas Kocher 1 Leibniz Institute for Plasma Science and Technology e.V. (INP Greifswald), Greifswald, Germany, 2 Unit of Periodontology, Dental School, University of Greifswald, Greifswald, Germany, 3 Centre for Innovation Competence Plasmatis, Greifswald, Germany, 4 Institute for Hygiene and Environmental Medicine, University of Greifswald, Greifswald, Germany Abstract Introduction: The medical use of non-thermal physical plasmas is intensively investigated for sterilization and surface modification of biomedical materials. A further promising application is the removal or etching of organic substances, e.g., biofilms, from surfaces, because remnants of biofilms after conventional cleaning procedures are capable to entertain inflammatory processes in the adjacent tissues. In general, contamination of surfaces by micro-organisms is a major source of problems in health care. Especially biofilms are the most common type of microbial growth in the human body and therefore, the complete removal of pathogens is mandatory for the prevention of inflammatory infiltrate. Physical plasmas offer a huge potential to inactivate micro-organisms and to remove organic materials through plasma-generated highly reactive agents. Method: In this study a Candida albicans biofilm, formed on polystyrene (PS) wafers, as a pr