beta-lapachone, a modulator of nad metabolism, prevents health declines in aged mice调制器的beta-lapachone nad新陈代谢,防止老鼠岁健康下降.pdfVIP

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice 1 1 2 3 3 4 Jeong-sook Lee , Ah Hyung Park , Sang-Hee Lee , Seoung-Hoon Lee , Jin-Hwan Kim , Suk-Jin Yang , 4 3 5 5 6 2 Young Il Yeom , Tae Hwan Kwak , Dongyeop Lee , Seung-Jae Lee , Chul-Ho Lee , Jin Man Kim , Daesoo Kim1* 1 Department of Biological Sciences, KAIST (Korea Advanced Institute of Science and Technology), Daejeon, Korea, 2 Department of Pathology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea, 3 RD Institute, Mazence Inc., Suwon, Korea, 4 Medical Genomics Research Center, KRIBB (Korea Research Institute of Bioscience and Biotechnology), Daejeon, Korea, 5 Division of Molecular and Life Science, POSTECH (Pohang University of Science and Technology), Pohang, Kyungbuk, Korea, 6 Animal Model Center, KRIBB (Korea Research Institute of Bioscience and Biotechnology), Daejeon, Korea Abstract + NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD /NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding b-lapachone (bL), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. bL-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and