bias in reporting of genetic association studies偏见的遗传关联研究的报告.pdfVIP

Open access, freely available online Synopses of Research Articles Manipulating Microtubules in Systemic Sclerosis DOI: 10.1371/journal.pmed.0020403 Systemic sclerosis (scleroderma family of proteins (R-Smads), some of or SSc) is the name for a group of which act to stimulate further TGFβ progressive diseases, all of which involve signaling, and others of which act to the abnormal growth of connective inhibit it. The microtubules regulate the tissue. They are chronic degenerative R-Smad access to and activation by TGFβ disorders in which there is widespread receptors. vascular deterioration and tissue loss. Dong and colleagues were able to The recognition of SSc dates back show that in this model of SSc, paclitaxel many years. Indeed, the characteristic markedly suppressed the activation of stretched thickening of the skin was two of the Smads, Smad2 and Smad3, probably fi rst described by Hippocrates. and, hence, collagen deposition in SSc A more defi nitive description of the grafts. They also