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BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma 1. 1. 2,9 3 Joseph H. Jeong , Zhenxiong Wang , Alexander S. Guimaraes , Xuesong Ouyang , Jose L. 2,9 1 1 1,8 4 5 Figueiredo , Zhihu Ding , Shan Jiang , Isil Guney , Gyeong Hoon Kang , Eyoung Shin , William C. 1,6,8 1,5,8 3 2,9,10 1,7 Hahn , Massimo F. Loda , Cory Abate-Shen , Ralph Weissleder , Lynda Chin * 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Urology and Pathology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, New York, United States of America, 4 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea, 5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 6 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 7 Department of Dermatology, Harvard Medical School, Boston, Massachusetts, United States of America, 8 Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, 9 Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard M