cellular model of warburg effect identifies tumor promoting function of ucp2 in breast cancer and its suppression by genipinwarburg效应细胞模型识别肿瘤的促进功能由genipin ucp2在乳腺癌及其抑制.pdfVIP

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cellular model of warburg effect identifies tumor promoting function of ucp2 in breast cancer and its suppression by genipinwarburg效应细胞模型识别肿瘤的促进功能由genipin ucp2在乳腺癌及其抑制.pdf

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cellular model of warburg effect identifies tumor promoting function of ucp2 in breast cancer and its suppression by genipinwarburg效应细胞模型识别肿瘤的促进功能由genipin ucp2在乳腺癌及其抑制

Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin 1. 1. 2 3 Vanniarajan Ayyasamy , Kjerstin M. Owens , Mohamed Mokhtar Desouki , Ping Liang , Andrei 1 4 5 6 1,7 Bakin , Kumarasamy Thangaraj , Donald J. Buchsbaum , Albert F. LoBuglio , Keshav K. Singh * 1 Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, United States of America, 2 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America, 3 Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada, 4 Centre for Cellular and Molecular Biology, Hyderabad, India, 5 Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 6 University of Alabama at Birmingham Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 7 Departments of Genetics, Pathology, Environmental Health, Center for Free Radical Biology, Center for Aging and University of Alabama at Birmingham Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Abstract The Warburg Effect is characterized by an irreversible injury to mitochondrial oxidative phosphorylation (OXPHOS) and an increased rate of aerobic glycolysis. In this study, we utilized a breast epithelial cell line lacking mitochondrial DNA (rho0) that exhibits the Warburg Eff