defining childhood severe falciparum malaria for intervention studies定义儿童严重恶性疟疾干预研究.pdfVIP

PLoS MEDICINE Defining Childhood Severe Falciparum Malaria for Intervention Studies 1,2* 1,2 1 1 1 1,3,4 Philip Bejon , James A. Berkley , Tabitha Mwangi , Edna Ogada , Isaiah Mwangi , Kathryn Maitland , Thomas Williams1,5 1,2 5,6 1,2 1 , J. Anthony G. Scott , Mike English , Brett S. Lowe , Norbert Peshu , Charles R. J. C. Newton1,7, Kevin Marsh1,2 1 Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, 2 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom, 3 Department of Paediatrics, Imperial College, London, United Kingdom, 4 Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College, London, United Kingdom, 5 Department of Paediatrics, The John Radcliffe Hospital University of Oxford, Oxford, United Kingdom, 6 Nairobi KEMRI–Wellcome Trust Collaborative Research Programme, Kenyatta National Hospital, Nairobi, Kenya, 7 Neurosciences Unit, Institute of Child Health, London, United Kingdom Funding: This study was supported A B S T R A C T by the KEMRI and the Wellcome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or Background preparation of the manuscript. Clinical trials of interventions designed to prevent severe falciparum