deletion of a malaria invasion gene reduces death and anemia, in model hosts删除疟疾入侵基因减少死亡和贫血,在主机模型.pdfVIP

Deletion of a Malaria Invasion Gene Reduces Death and Anemia, in Model Hosts ´ ´ 1,2 1 1 3 2 Noe D. Gomez , Innocent Safeukui , Aanuoluwa A. Adelani , Rita Tewari , Janardan K. Reddy , Sam 2 4 5 6 1 Rao , Anthony Holder , Pierre Buffet , Narla Mohandas , Kasturi Haldar * 1 Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, Indiana, United States of America, 2 Feinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, Illinois, United States of America, 3 Centre for Genetics and Genomics, School of Biology, University of Nottingham, ´ Nottingham, United Kingdom, 4 Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom, 5 Inserm-UPMC (Paris 6 University) Unite Mixte de Recherche s945, Paris, France, 6 New York Blood Center, New York, New York, United States of America Abstract Malaria parasites induce complex cellular and clinical phenotypes, including anemia, cerebral malaria and death in a wide range of mammalian hosts. Host genes and parasite ‘toxins’ have been implicated in malarial disease, but the contribution of parasite genes remains to be fully defined. Here we assess disease in BALB/c mice and Wistar rats infected by the rodent malaria parasite Plasmodium berghei with a gene knock out for merozoite surface protein (MSP) 7. MSP7 is not essential for infection but in P. falciparum, it enhan