dermal-type macrophages expressing cd209dc-sign show inherent resistance to dengue virus growthdermal-type巨噬细胞表达cd209dc-sign显示固有抗登革病毒的增长.pdfVIP

Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth 1,2,3. 4,5. ´ ` 1 1 Wing-Hong Kwan , Erika Navarro-Sanchez , Helene Dumortier , Marion Decossas , Hortense 1 6 ´ 2,3 ´ 5 6 4 Vachon , Flavia Barreto dos Santos , Herve W. Fridman , Felix A. Rey , Eva Harris , Philippe Despres *, Christopher G. Mueller1* ´ ´ 1 CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Universite Louis Pasteur, Strasbourg, France, 2 INSERM U872, Centre de Recherches Biomedicales ´ ´ ´ des Cordeliers, Paris V UMRS 872, France, 3 INSERM U872, Centre de Recherches Biomedicales des Cordeliers, Paris VI UMRS 872, France, 4 Unite Interactions Moleculaires ˆ ´ Flavivirus-Hotes, Institut Pasteur, Paris, France, 5 Unite de Recherche de Virologie Structurale, CNRS URA 3015, Institut Pasteur, Paris, France, 6 Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California, United States of America Abstract Background: An important question in dengue pathogenesis is the identity of immune cells involved in the control of dengue virus infection at the site of the mosquito bite. There is evidence that infect