developmental patterns of doublecortin expression and white matter neuron density in the postnatal primate prefrontal cortex and schizophrenia发展模式doublecortin表达式和白质神经元密度在产后灵长类动物前额叶皮层和精神分裂症.pdfVIP

Developmental Patterns of Doublecortin Expression and White Matter Neuron Density in the Postnatal Primate Prefrontal Cortex and Schizophrenia Samantha J. Fung1,2,3*, Dipesh Joshi1,2, Katherine M. Allen1,2,4, Sinthuja Sivagnanasundaram1,2, 1,2 5 6 7 Debora A. Rothmond , Richard Saunders , Pamela L. Noble , Maree J. Webster , Cynthia Shannon Weickert1,2,4 1 Schizophrenia Research Institute, Sydney, Australia, 2 Neuroscience Research Australia, Sydney, Australia, 3 School of Medical Sciences, University of New South Wales, Sydney, Australia, 4 School of Psychiatry, University of New South Wales, Sydney, Australia, 5 Laboratory of Neuropsychology, National Institute of Mental Health (NIMH), National Institutes of Health, Bethesda, Maryland, United States of America, 6 National Institute of Mental Health (NIMH) IRP Non-Human Primate Core, Poolesville, Maryland, United States of America, 7 Stanley Medical Research Institute, Rockville, Maryland, United States of America Abstract Postnatal neurogenesis occurs in the subventricular zone and dentate gyrus, and evidence suggests that new neurons may be present in additional regions of the mature primate brain, including the prefrontal cortex (PFC). Addition of new neurons to the PFC implies local generation of neurons or migration from areas such as the subventricular zone. We examined the putative contribution of new, migrating neurons to postnatal cortical development by determining the density of neurons in white matter subjacent to the cortex and measuring expression of doublecortin (DCX), a microtubule-associated protein involved in neuronal migration, in humans and rhesus macaques. We found a striking decline in DCX expression (human and macaque) and density of white matter neurons (humans) during infan