developmental expression of kv potassium channels at the axon initial segment of cultured hippocampal neurons发展kv钾离子通道的表达在培养海马神经元的轴突初始段.pdfVIP

Developmental Expression of Kv Potassium Channels at the Axon Initial Segment of Cultured Hippocampal Neurons ´ 1,2,3,4 1,3,5 ´ 2,5 ˜ 1,3,4 Diana Sanchez-Ponce , Javier DeFelipe , Juan Jose Garrido *, Alberto Munoz * ´ 1 Department of Functional and Systems Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientıficas, Madrid, Spain, 2 Department of Molecular, Cellular ´ and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientıficas, Madrid, Spain, 3 Laboratorio Cajal de Circuitos Corticales, Centro de ´ ´ ´ ´ Tecnologıa Biomedica, Universidad Politecnica de Madrid, Madrid, Spain, 4 Department of Cell Biology, Complutense University, Madrid, Spain, 5 Centro de Investigacion ´ Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Abstract Axonal outgrowth and the formation of the axon initial segment (AIS) are early events in the acquisition of neuronal polarity. The AIS is characterized by a high concentration of voltage-dependent sodium and potassium channels. However, the specific ion channel subunits present and their precise localization in this axonal subdomain vary both during development and among the types of neurons, probably determining their firing characteristics