differentiating the cognitive profile of schizophrenia from that of alzheimer disease and depression in late life差异化的认知形象与阿尔茨海默病精神分裂症和抑郁症在后期的生活.pdfVIP

Differentiating the Cognitive Profile of Schizophrenia from That of Alzheimer Disease and Depression in Late Life 1 1,2 1,2,3 1,4 1 Christina Ting , Tarek K. Rajji *, Zahinoor Ismail , David F. Tang-Wai , Nina Apanasiewicz , Dielle Miranda1, David Mamo1,2, Benoit H. Mulsant1,2 1 Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, 2 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, 3 Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada, 4 Division of Neurology, University of Toronto, Toronto, Ontario, Canada Abstract Background: To compare the cognitive profile of older patients with schizophrenia to those with other neuropsychiatric disorders assessed in a hospital-based memory clinic. Methods: Demographic, clinical, and cognitive data of all patients referred to the memory clinic at the Centre for Addiction and Mental Health between April 1, 2006 and August 15, 2008 were reviewed. We then identified four groups of older patients with: (1) late-life schizophrenia (LLS) and no dementia or depression (DEP); (2) Alzheimer’s disease (AD); (3) DEP and no dementia or LLS; (4) normal cognition (NC) and no DEP or LLS. Results: The four groups did not differ in demographic data except that patients with AD were about 12 years older than those with LLS. However, they differed on cognitive tests even after controlling for age. Patients with LLS were impaired on most cognitive tests in comparison with patients with NC but not on recalling newly learned verbal information at a short delay. They experienced equivalent performance on learning new verbal information in comparison with patients with AD, but better