diffusion spectrum imaging shows the structural basis of functional cerebellar circuits in the human cerebellum in vivo扩散光谱成像显示小脑功能的结构基础电路在人类小脑体内.pdfVIP

Diffusion Spectrum Imaging Shows the Structural Basis of Functional Cerebellar Circuits in the Human Cerebellum In Vivo 1 2 3,4 5 6 Cristina Granziera *, Jeremy Dan Schmahmann , Nouchine Hadjikhani , Heiko Meyer , Reto Meuli , Van Wedeen3, Gunnar Krueger7 1 Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 2 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical ´ ´ School, Charlestown, Massachusetts, United States of America, 4 Brain Mind Institute, Ecole polytechnique federale, Lausanne, Switzerland, 5 Siemens AG, H IM MR PLM AW Neurology, Erlangen, Germany, 6 Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 7 Siemens Schweiz AG, Healthcare Sector IMWS S, Renens, Switzerland Abstract Background: The cerebellum is a complex structure that can be affected by several congenital and acquired diseases leading to alteration of its function and neuronal circuits. Identifying the structural bases of cerebellar neuronal networks in humans in vivo may provide biomarkers for diagnosis and management of cerebellar diseases. Objectives: To define the anatomy of intrinsic and extrinsic cerebellar circuits using high-angular resolution diffusion spectrum imaging (DSI). Methods: We acquired high-resolution structural MRI and DSI of the cerebellum in four healthy female subjects at 3T. DSI tractography based o