distinct roles of microrna-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytesmicrorna-1和-499室规范中截然不同的角色和功能成熟的人类胚胎干细胞心肌细胞.pdfVIP

Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes 1 1,2 1,2 1,3,4 3,6,7 Ji-Dong Fu , Stephanie N. Rushing , Deborah K. Lieu , Camie W. Chan , Chi-Wing Kong , Lin 6 8 1 6,9 8 Geng , Kitchener D. Wilson , Nipavan Chiamvimonvat , Kenneth R. Boheler , Joseph C. Wu , Gordon 10 2 1,2,3,5,6,7 Keller , Roger J. Hajjar , Ronald A. Li * 1 University of California School of Medicine, Davis, California, United States of America, 2 Center of Cardiovascular Research, Mount Sinai School of Medicine, New York, New York, United States of America, 3 Department of Medicine, The University of Hong Kong, Hong Kong, 4 Department of Anatomy, The University of Hong Kong, Hong Kong, 5 Department of Physiology, The University of Hong Kong, Hong Kong, 6 Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Hong Kong, 7 Heart, Brain, Hormone and Healthy Aging Research Center, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, 8 Departments of Medicine and Radiology, Stanford University, Palo Alto, California, United States of America, 9 Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 10 McEwen Central for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada Abstract Background: MicroRNAs (miRs) negatively regulate trans